CAS号：129-43-1
|
英文名称：1-Hydroxy anthraquinone
分子式
C14H8O3
分子量
224
EINECS号
204-946-7
MDL
MFCD00058946
Smiles
C1(O)=C2C(C(=O)C3=C(C2=O)C=CC=C3)=CC=C1
InChIKey
BTLXPCBPYBNQNR-UHFFFAOYSA-N
1-羟基蒽醌化学百科
基本信息
| 中文名称 | 1-羟基蒽醌 |
| 英文名称 | 1-Hydroxy anthraquinone |
| CAS号 | 129-43-1 |
| 分子式 | C14H8O3 |
| 分子量 | 224.21 |
| EINECS号 | 204-946-7 |
物化性质
| 熔点 | 194°C |
| 沸点 | 325.61°C (rough estimate) |
| 密度 | 1.2337 (rough estimate) |
| 折射率 | 1.5400 (estimate) |
| 溶解度 | 氯仿：30mg/mL |
| 形态 | 粉末晶体 |
| 酸度系数(pKa) | 7.15±0.20(Predicted) |
| 颜色 | 浅黄色至棕色 |
| (IARC)致癌物分类 | 2B (Vol. 82) 2002 |
安全信息
| 危险品标志 | Xn |
| 危险类别码 | 36/37/38-40-36 |
| 安全说明 | 26-36/37/39-45 |
| RTECS号 | CB7178000 |
| 海关编码 | 2914.69.9000 |
| 毒害物质数据 | 129-43-1(Hazardous Substances Data) |
生产及用途
1-Hydroxyanthraquinone 是具有口服活性的天然产物，可来源于一些植物如 Tabebuia avellanedae，具有致癌作用。
1-Hydroxyanthraquinone (HA) generates strong DNA repair response and is carcinogenic in rats.
| Animal Model: | Thirty rats. |
| Dosage: | 1% HA in diet. |
| Administration: | Diet. |
| Result: |
Associated with decreased weight gain which was particularly marked towards the termination of experiment.
One of the 30 rats in group 1 (experimental group) died of pneumonia 243 days after the start of experiment. A second rat died in an unnourished state at day 280, demonstrating a large tumor in the colon. Seven animals of the group died spontaneously or were sacrificed upon becoming moribund between 335 and 462 days. A total of 21 rats of group 1 survived until the end of experiment (mean value of total intake of HA/rat was 76.8 g). |
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