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CAS号:148-72-1
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英文名称:Pilocarpine nitrate
分子式
C11H17N3O5
分子量
271
EINECS号
205-723-7
MDL
MFCD00078497
Smiles
[C@@H]1(CC2=CN=CN2C)[C@H](CC)C(OC1)=O.[N+]([O-])(=O)O |&1:0,8,r|
InChIKey
PRZXEPJJHQYOGF-BZDPORMQNA-N
乙二醇化学百科
基本信息
物化性质
安全信息
生产及用途
硝酸毛果芸香碱呈无色结晶或白色结晶性粉末;无臭;遇光易变质。其可用于青光眼、虹膜炎的治疗。 1.对本药过敏者。 2.支气管哮喘患者。 3.急性虹膜炎、虹膜睫状体炎等不应缩瞳的眼病患者。 Pilocarpine nitrate 是一种选择性的 M3 型毒蕈碱乙酰胆碱受体 (M3 muscarinic receptor) 激动剂。M3 muscarinic receptor To evaluate the cytotoxicity of Pilocarpine, the morphology and viability of human corneal stromal (HCS) cells are examined by light microscopy and MTT assay, respectively. Morphological observations show that HCS cells exposed to Pilocarpine at a concentration from 0.625 to 20 g/L exhibit dose- and time-dependent proliferation retardation and morphological abnormality such as cellular shrinkage, cytoplasmic vacuolation, detachment from culture matrix, and eventually death, while no obvious difference is observed between those exposed to Pilocarpine below the concentration of 0.625 g/L and controls. Results of MTT assay reveal that the cell viability of HCS cells decrease with time and concentration after exposing to Pilocarpine above the concentration of 0.625 g/L (P<0.01 or 0.05), while that of HCS cells treated with Pilocarpine below the concentration of 0.625 g/L show no significant difference to controls. The partial muscarinic agonist, Pilocarpine, evokes concentration-dependent relaxation with an EC 50 of 2.4 mM in isolated segments of rat tail artery that were constricted with Penylephrine (10 to 200 nM).
The Pilocarpine-induced saliva secretion of the control rats (CN) and exercised (EX) rats is examined. A significantly greater amount of saliva is induced by Pilocarpine in the EX rats than in the CN rats (P<0.01). Conversely, the Na + concentration in the saliva of the EX rats is significantly lower than that of the CN rats (P<0.05).
生产方法
可由植物毛果芸香提取毛果芸香碱后,再用硝酸处理而制得。
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