CasImg
硝酸毛果芸香碱
产品纠错
CAS号:148-72-1 | 英文名称:Pilocarpine nitrate
分子式 C11H17N3O5
分子量 271
EINECS号 205-723-7
MDL MFCD00078497
Smiles [C@@H]1(CC2=CN=CN2C)[C@H](CC)C(OC1)=O.[N+]([O-])(=O)O |&1:0,8,r|
InChIKey PRZXEPJJHQYOGF-BZDPORMQNA-N
乙二醇化学百科
基本信息
中文名称 硝酸毛果芸香碱
英文名称 Pilocarpine nitrate
CAS号 148-72-1
分子式 C11H17N3O5
分子量 271.27
EINECS号 205-723-7
物化性质
熔点 173,5-174°C
比旋光度 D +77 to +83° (c = 10)
折射率 81 ° (C=2, H2O)
溶解度 在水中的溶解度0.1 g/mL,清澈,非常淡黄色
形态 粉末
颜色 白色
旋光性 (optical activity) [α]25/D +83°, c = 10 in H2O(lit.)
Merck 14,7424
BRN 4171406
安全信息
危险品标志 Xn,T+
危险类别码 22-26/28
安全说明 1-25-45
危险品运输编号 3087
WGK Germany 3
RTECS号 TK1455000
F 3-10
海关编码 2939800000
危险等级 6.1(b)
包装类别 III
毒性 LD50 oral in rat: 911mg/kg
生产及用途

硝酸毛果芸香碱呈无色结晶或白色结晶性粉末;无臭;遇光易变质。其可用于青光眼、虹膜炎的治疗。

1.对本药过敏者。

2.支气管哮喘患者。

3.急性虹膜炎、虹膜睫状体炎等不应缩瞳的眼病患者。

Pilocarpine nitrate 是一种选择性的 M3 型毒蕈碱乙酰胆碱受体 (M3 muscarinic receptor) 激动剂。

M3 muscarinic receptor

To evaluate the cytotoxicity of Pilocarpine, the morphology and viability of human corneal stromal (HCS) cells are examined by light microscopy and MTT assay, respectively. Morphological observations show that HCS cells exposed to Pilocarpine at a concentration from 0.625 to 20 g/L exhibit dose- and time-dependent proliferation retardation and morphological abnormality such as cellular shrinkage, cytoplasmic vacuolation, detachment from culture matrix, and eventually death, while no obvious difference is observed between those exposed to Pilocarpine below the concentration of 0.625 g/L and controls. Results of MTT assay reveal that the cell viability of HCS cells decrease with time and concentration after exposing to Pilocarpine above the concentration of 0.625 g/L (P<0.01 or 0.05), while that of HCS cells treated with Pilocarpine below the concentration of 0.625 g/L show no significant difference to controls. The partial muscarinic agonist, Pilocarpine, evokes concentration-dependent relaxation with an EC 50 of 2.4 mM in isolated segments of rat tail artery that were constricted with Penylephrine (10 to 200 nM).

The Pilocarpine-induced saliva secretion of the control rats (CN) and exercised (EX) rats is examined. A significantly greater amount of saliva is induced by Pilocarpine in the EX rats than in the CN rats (P<0.01). Conversely, the Na + concentration in the saliva of the EX rats is significantly lower than that of the CN rats (P<0.05).

生产方法 

可由植物毛果芸香提取毛果芸香碱后,再用硝酸处理而制得。

上下游产品
上游产品共计:2个
下游产品共计:0个
产品供应商

首页 |  CAS目录 |  产品目录 |  企业会员 |  关于我们 |  法律声明 |  注册协议

Copyright © 冀ICP备2024096099号