| 中文名称 | L(+)-2-氨基-4-膦酰基丁酸 |
| 英文名称 | L-AP4 |
| CAS号 | 23052-81-5 |
| 分子式 | C4H10NO5P |
| 分子量 | 183.1 |
| EINECS号 | 200-258-5 |
| 熔点 | 207-215 °C |
| 沸点 | 491.7±55.0 °C(Predicted) |
| 密度 | 1.628±0.06 g/cm3(Predicted) |
| 溶解度 | H2O：50 mg/mL（273.07 mM；需要超声波） |
| 形态 | 固体 |
| 酸度系数(pKa) | 2.19±0.10(Predicted) |
| 颜色 | 白色 |
| 水溶解性 | Soluble to 5 mM in water and to 100 mM in 1eq. NaOH |
| 敏感性 | Light Sensitive |
| 危险品标志 | Xi |
| 危险类别码 | 36/37/38 |
| 安全说明 | 26-36 |
| WGK Germany | 3 |
| RTECS号 | ES7191700 |
|
mGlu 4 0.13 μM (EC 50 ) |
mGlu8 0.29 μM (EC 50 ) |
mGlu 6 1.0 μM (EC 50 ) |
mGlu7 249 μM (EC 50 ) |
Paw withdrawal threshold in response to application of von Frey filaments before spinal nerve ligation is 22.6±2.4 g. The mechanical threshold decreases significantly (2.3±0.5 g, P<0.05) within 10 days after nerve ligation and remains stable for at least 8 weeks. Intrathecal injection of 5 to 30 μg of L-APB significantly increases the paw withdrawal threshold in response to application of von Frey filaments in eight nerve-ligated rats in a dose-dependent manner. The maximal effect of L-APB appears within 45 min and gradually subsided in 120 min following intrathecal administration.