Oxytocin acetate 是一种多效的下丘脑肽 (hypothalamic peptide),有助于分娩、哺乳和亲社会行为。Oxytocin acetate 可以作为一种压力应对分子,具有抗炎、抗氧化剂和保护作用,特别是在面对逆境或创伤时。
During the LMA task, rat core body temperature are modestly decreased. Oxytocin acetate (subcutaneous injection; 0.1 mg/kg-0.3 mg/kg; single dose) produces significantly greater hypothermia (at 0.3 mg/kg) than either saline or the two lower doses of oxytocin. Oxytocin at 0.3 mg/kg produces a significantly greater decrease in temperature than vehicle between 15-60 min post injection, whereas 0.1 mg/kg slightly decreases temperature at the 30 min time point only.Oxytocin acetate (0.1 mg/kg) engages in significantly more body sniffing and ano-genital sniffing compared with saline controls. It also increases the total time spent in social interaction (71.6±4.3 s), compared to those receiving vehicle (56.9±4.1 s).
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Animal Model:
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Fifty-six male Lister-hooded rats (150–200 g)
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Dosage:
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0.1 mg/kg-0.3 mg/kg
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Administration:
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Subcutaneous injection; 0.1 mg/kg-0.3 mg/kg; single dose
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Result:
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Produced significantly greater hypothermia (at 0.3 mg/kg) than the saline group.
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多肽
醋酸缩宫素是一种肽类激素。催产素由垂体后叶分泌。由下丘脑室旁核和视上核合成。醋酸缩宫素由9个氨基酸组成和醋酸。生理作用:刺激乳腺分泌乳汁,在分娩过程中促进子宫平滑肌的收缩。此外,它还能减少人体内肾上腺酮等压力激素的水平,以降低血压。
参考质量标准
外观:白色粉末
纯度 (HPLC) ≥98.0%
醋酸根含量(HPLC): 6.0%~10.0%
水分含量(Karl Fischer) ≤8.0%