| 中文名称 | Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside |
| 英文名称 | Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside |
| CAS号 | 68027-15-6 |
| 分子式 | C47H76O17 |
| 分子量 | 913.09614 |
| EINECS号 | 211-708-6 |
| 熔点 | 239-241℃ |
| 沸点 | 997.6±65.0 °C(Predicted) |
| 密度 | 1.40±0.1 g/cm3 (20 ºC 760 Torr) |
| 溶解度 | 少许溶于甲醇、可溶于吡啶 |
| 形态 | 固体 |
| 酸度系数(pKa) | 4.63±0.70(Predicted) |
| 颜色 | 白色至浅米色 |
| Target | Value |
|
c-Met
() |
Pulsatilla saponin D (SB365) shows apoptotic effect accompanied by increased evidence of cleaved caspase-3 and poly (ADP ribose) polymerase.
Pulsatilla saponin D (SB365) strongly inhibits c-Met expression in gastric cancer cells.
Pulsatilla saponin D (SB365) strongly suppresses the growth and proliferation of 5 human pancreatic cancer cell lines (MIAPaCa-2, BXPC-3, PANC-1, AsPC-1 and HPAC) .
Pulsatilla saponin D (SB365) shows anti-angiogenic activity by decreasing the expression of HIF-1α and VEGF.
Pulsatilla saponin D (0.3 ng/mL to 10 μg/mL) exhibits anti-tumor activity in NSCLC cancer cells.
Cell Cytotoxicity Assay
| Cell Line: | A-549, SKMEL-2, MCF-7, and Lewis lung carcinoma (LLC) cells. |
| Concentration: | 0.3 ng/mL to 10 μg/mL. |
| Incubation Time: | 72 h. |
| Result: | Exhibited an ED 50 value of 6.3 μg/mL for A-549 cells. |
Pulsatilla saponin D (6.4 mg/kg) exhibits anti-tumor activity in Lewis lung carcinoma model.
| Animal Model: | 2x2x2 mm 3 tumor fragments of a Lewis lung carcinoma (LLC) transplanted s.c. into the auxiliary region of the BDF1 mice. |
| Dosage: | 6.4 mg/kg. |
| Administration: | Intraperitoneally on the 1 st to 7 th and 9 th to 14 th day. |
| Result: | Had such a potent antitumor effect (IR, 82 %) on a solid tumor, which is higher than Adriamycin (IR, 64%). |
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CAS号:129741-57-7
白头翁皂苷B4 -
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白头翁皂苷 H -
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黄花败酱甙C -
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白头翁皂苷B -
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白头翁皂苷A3 -
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Lup-20(29)-en-28-oic acid, 3-[β-D-glucopyranosyl(1→4)[a-L-rhamnopyranosyl) (1→2)-a -L-arabinopyran -
CAS号:366814-43-9
白头翁皂苷E -
CAS号:33783-82-3
Hederacolchiside E -
CAS号:32181-59-2
N -乙酰- D- 乳糖胺 -
CAS号:106577-39-3
Hederacolchiside A1 -
CAS号:129741-57-7
白头翁皂苷B4 -
CAS号:68027-14-5
白头翁皂苷 H -
CAS号:17233-22-6
黄花败酱甙C -
CAS号:135247-95-9
白头翁皂苷B -
CAS号:129724-84-1
白头翁皂苷A3 -
CAS号:848784-87-2
Lup-20(29)-en-28-oic acid, 3-[β-D-glucopyranosyl(1→4)[a-L-rhamnopyranosyl) (1→2)-a -L-arabinopyran -
CAS号:366814-43-9
白头翁皂苷E -
CAS号:33783-82-3
Hederacolchiside E -
CAS号:32181-59-2
N -乙酰- D- 乳糖胺 -
CAS号:106577-39-3
Hederacolchiside A1