| 中文名称 | 米库氯铵 |
| 英文名称 | Mivacurium chloride |
| CAS号 | 106861-44-3 |
| 分子式 | C58H80ClN2O14+ |
| 分子量 | 1064.73 |
| EINECS号 | 643-006-4 |
| 比旋光度 | 20D -62.7° (c = 1.9 in water) |
| 溶解度 | DMSO:可溶;水溶性 |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
| 稳定性 | 吸湿性 |
Mivacurium induces LAD2 cell degranulation in a dose-dependent manner. Mivacurium stimulates intracellular Ca 2+ influx in MRGPRX2-HEK293 cells but not in NC-HEK293 cells. Mivacurium induces the release of only low levels of mediators in LAD2 cells transfected with MRGPRX2-targeted small interfering siRNA.
Mivacurium causes pseudo-allergic reactions in C57 wild-type mice by inducing mast cells to release histamine and a decrease in body temperature.
Mivacurium is rapidly hydrolyzed in the plasma and has a short duration of action (< 10 min). Mivacurium has many advantages, such as a rapid effect, nonneurological toxicity and a lack of heart rate alteration.