| 中文名称 | 硫培南 |
| 英文名称 | Sulopenem |
| CAS号 | 120788-07-0 |
| 分子式 | C12H15NO5S3 |
| 分子量 | 349.45 |
| EINECS号 | 604-604-1 |
| 沸点 | 693.1±55.0 °C(Predicted) |
| 密度 | 1.74±0.1 g/cm3(Predicted) |
| 形态 | 固体 |
| 酸度系数(pKa) | 3.88±0.40(Predicted) |
| 颜色 | 白色至黄色 |
硫培南是一种具有口服活性的肠胃外青霉烯类抗生素，对革兰氏阳性菌和革兰氏阴性菌具有广谱活性。它可用于尿路感染和腹腔内感染的研究，它对铜绿假单胞菌和嗜黄单胞菌的嗜麦芽孢杆菌无效。
MIC: 0.015-0.12 µg/mL ( E. coli )
Sulopenem has the potential for uncomplicated and complicated urinary tract infections and intra-abdominal infections treatment, including multidrug-resistant (MDR) infections and infections attributable to quinolone-nonsusceptible and/or extended-spectrum β-lactamase (ESBL)-producing Gram-negative bacilli.
Sulopenem inhibits the growth of most isolates of aerobic and anaerobic Gram-positive and Gram-negative bacteria, including methicillin-susceptible
Staphylococcus aureus
,
Streptococcus pneumoniae
(penicillin-susceptible and -resistant isolates), group A and B β-hemolytic streptococci,
Listeria monocytogenes
,
Enterobacteriaceae
,
Haemophilus influenzae
, and
Moraxella catarrhalis
but excluding
P. aeruginosa
and
Stenotrophomonas maltophilia
, at a concentration of ≤1 μg/mL.
The protective effects of Sulopenem in murine experimental systemic infections are superior to those of Imipenem/Cilastatin. In murine experimental mixed infection with Escherichia coli and Bacteroides fragilis , Sulopenem has lower ED 50 . In guinea pigs experimental lung infection with Klebsiella pneumoniae , Sulopenem is more effective than CZON or Cefotiam.