CasImg
非诺特罗
产品纠错
CAS号:13392-18-2 | 英文名称:Fenoterol
分子式 C17H21NO4
分子量 303
EINECS号
MDL MFCD00242675
Smiles
InChIKey
乙二醇化学百科
基本信息
中文名称 非诺特罗
英文名称 Fenoterol
CAS号 13392-18-2
分子式 C17H21NO4
分子量 303.35
EINECS号 680-817-2
物化性质
熔点 181-183°C
沸点 566.0±45.0 °C(Predicted)
密度 1.289±0.06 g/cm3(Predicted)
形态 固体
酸度系数(pKa) pKa 8.5 (Uncertain);10.0 (Uncertain)
颜色 浅棕色至棕色
安全信息
生产及用途
Fenoterol (Phenoterol) 是β2 adrenoreceptor激动剂,具有支气管扩张活性。
TargetValue
β2 adrenoreceptor
()

Fenoterol (1 μM; pre-incubated 30 minutes) treatment reduces AICAR-induced AMPK activation, NF-κB activation and TNF-α release, and also significantly downregulates the elevated phosphorylation levels of AMPK.
Fenoterol inhibits lipopolysaccharide (LPS)-induced AMPK activation and inflammatory cytokine production in THP-1 cells.
Fenoterol is also a potent exosome biogenesis and/or secretion activator in PC cells.

Western Blot Analysis

Cell Line: THP-1 cells stimulated with AICAR
Concentration: 1 μM
Incubation Time: Pre-incubated 30 minutes
Result: Significantly downregulated the elevated phosphorylation levels of AMPK.

Fenoterol (0.7 mg/kg; intraperitoneal injection; twice a day; for 3 weeks) treatment suppresses mechanical allodynia during chronic treatment.

Animal Model: Male C57BL/6J mice (6 weeks old) with neuropathy
Dosage: 0.7 mg/kg
Administration: Intraperitoneal injection; twice a day; for 3 weeks
Result: Alleviated neuropathic allodynia during chronic treatment.
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