| 中文名称 | 泰乐菌素 |
| 英文名称 | Tylosin |
| CAS号 | 1401-69-0 |
| 分子式 | C46H77NO17 |
| 分子量 | 916.1 |
| EINECS号 | 215-754-8 |
| 熔点 | 135-137°C |
| 比旋光度 | D25 -46° (c = 2 in methanol) |
| 沸点 | 796.05°C (rough estimate) |
| 密度 | 1.1424 (rough estimate) |
| 折射率 | 1.5280 (estimate) |
| 溶解度 | DMF:30mg/mL; DMSO:25mg/mL;乙醇:30mg/mL |
| 形态 | 结晶固体 |
| 酸度系数(pKa) | pKa 7.73(H2Ot = 25I = 0.167) (Uncertain) |
| 颜色 | 白色至浅黄色 |
| 水溶解性 | H2O: soluble 50 mg/mL |
| 稳定性 | Solutions are stable at pH 4-9 (most stable at pH 7);Below pH 4 tylosin B (desmycosin) is formed as a result of acid hydrolysis;In neutral and alkaline pH – tylosin aldol (TAD) is formed together with polar degradation products of unknown identity;When tylosin solution is exposed to daylight, a photodegradation product - isotylosin A (isoTA) is formed. |
| 危险品标志 | Xn,N |
| 危险类别码 | 42/43-50 |
| 安全说明 | 36-61-45-36/37-22 |
| 海关编码 | 2941906000 |
| 毒害物质数据 | 1401-69-0(Hazardous Substances Data) |
| 毒性 | Tylosin base and its salts were shown to be of low acute oral toxicity with LD50 values in excess 5000 mg/kg bw in the rat and mouse and greater than 800 mg/kg bw in the dog. |
Antibiotic
Tylosin exerts antibacterial effects by binding to 23S rRNA of the bacterial ribosomal 50S subunit .
Tylosin also prevents growth of Gram-negative strains, with MICs of 64 μg/mL, 32 μg/mL, 512 μg/mL and 1 μg/mL for
M. haemolytica
11935,
P. multocida
4407,
E. coli
ATCC 25922 and
E. coli
AS19rlmA
I
, respectively.
Tylosin (10-500 mg/kg; s.c.) generally suppresses the elevated TNF-α and IL-1β levels and increases the IL-10 levels in the Lipopolysaccharide (LPS) -treated animals.
| Animal Model: | Balb/C mice (2-3 months old, 20-25 g) |
| Dosage: | 10 mg/kg, 100 mg/kg, 500 mg/kg |
| Administration: | Subcutaneous injection |
| Result: | Reduced the elevated TNF-α and IL-1β in LPS (250 µg)-treated mice but increased their IL-10 levels. |