| 中文名称 | 顺式-8，11，14-二十烷三烯酸甲酯 |
| 英文名称 | CIS-8,11,14-EICOSATRIENOIC ACID |
| CAS号 | 1783-84-2 |
| 分子式 | C20H34O2 |
| 分子量 | 306.48 |
| EINECS号 | 217-233-0 |
| 沸点 | 200°C(lit.) |
| 密度 | 0.917±0.06 g/cm3(Predicted) |
| 折射率 | n20/D 1.478(lit.) |
| 闪点 | 144 °F |
| 溶解度 | 氯仿：50 mg/mL，澄清，无色 |
| 形态 | 液体 |
| 酸度系数(pKa) | 4.77±0.10(Predicted) |
| 颜色 | 无色至淡黄色 |
| BRN | 1796533 |
| 稳定性 | 感光 |
| 安全说明 | 23-24/25 |
| 危险品运输编号 | NA 1993 / PGIII |
| WGK Germany | 3 |
| RTECS号 | JX3880000 |
| 海关编码 | 2916.19.3000 |
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Human Endogenous Metabolite
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Dihomo-γ-linolenic acid attenuates pro-inflammatory gene expression in human and mouse macrophages.
Dihomo-γ-linolenic acid (50 μM; 24 hours) attenuates IFN-γ induced phosphorylation of STAT1 on serine 727.
Dihomo-γ-linolenic acid attenuates IL-1β and TNF-α induced MCP-1 and ICAM-1 expression in human macrophages.
Dihomo-γ-linolenic acid attenuates chemokine-driven monocytic migration and macrophage foam cell formation.
Dihomo-γ-linolenic acid attenuates the expression of SR-A and CD36 in human macrophages.
Dihomo-γ-linolenic acid modulates mitochondrial respiration.
Dihomo-γ-linolenic acid modulates the properties of endothelial cells and VSMC.
Western Blot Analysis
| Cell Line: | THP-1 macrophages |
| Concentration: | 50 μM (pre-treated) |
| Incubation Time: | 24 hours |
| Result: | Attenuated IFN-γ induced phosphorylation of STAT1 on serine 727. |
Dihomo-γ-linolenic acid (8 mg/mouse; i.g; twice a week; for 35 days) inhibits growth of xenograft tumors in mice bearing human pancreatic cancer cells (BxPC-3) transfected with delta-5-desaturase shRNA.
| Animal Model: | Female nude mice (48 four-week old) |
| Dosage: | 8 mg/mouse |
| Administration: | Oral gavage, twice a week, for 35 days |
| Result: | Suppressed metastasis potential in D5D-KD tumors. |
