米帕明 IMIPRAMINE CAS#:50-49-7

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产品纠错

CAS号：50-49-7 | 英文名称：IMIPRAMINE

分子式 C₁₉H₂₄N₂

分子量 280

EINECS号 200-042-1

MDL MFCD00242921

Smiles

InChIKey

乙二醇化学百科

基本信息

中文名称	米帕明
英文名称	IMIPRAMINE
CAS号	50-49-7
分子式	C19H24N2
分子量	280.41
EINECS号	200-042-1

物化性质

熔点	174°C
沸点	bp0.1 160°
密度	0.9935 (rough estimate)
折射率	1.5640 (estimate)
形态	液体
酸度系数(pKa)	pKa 9.66(H2O,t = 25,I=0.025) (Uncertain)
颜色	无色至浅黄
水溶解性	18.23mg/L(24 ºC)
Concentration	1 mCi/ml
Solvent	Ethanol under nitrogen
Specific Activity	60-90 Ci/mmol

安全信息

毒害物质数据

50-49-7(Hazardous Substances Data)

毒性

A tertiary amine tricyclic antidepressant that is thoughtto exert its therapeutic effect by inhibiting the reuptake of serotoninand norepinephrine centrally. A major metabolite is N-desmethylimipramine(desipramine), also used as an antidepressantdrug. Desipramine differs from imipramine in being a betterblocker of norepinephrine, rather than serotonin, uptake. Sideeffects, including sedation and drowsiness, dry mouth, urinaryretention, constipation, and orthostatic hypotension, are probablydue to the anticholinergic, anti-α-adrenergic, and antihistaminergicreceptor-blocking properties. Imipramine should not be usedin conjunction with a monoamine oxidase inhibitor or othertreatment that increases catecholamine concentrations (e.g.,drugs containing sympathomimetic amines). Imipramine shouldbe avoided in patients with cardiovascular disease or seizure disorder,or in those who may abuse alcohol, as imipramine lowersseizure threshold, can produce cardiovascular toxicity and maypotentiate the effects of alcohol. Imipramine intoxication caninclude CNS abnormalities (e.g., drowsiness, stupor, coma, andextrapyramidal symptoms), cardiac arrhythmia, and respiratorydepression. Children appear to be particularly vulnerable to thecardiotoxic and seizure-inducing effects of high doses of imipramine.The oral LD50 in female rats is 305 mg/kg.

生产及用途

生产方法

由邻硝基甲苯经缩合、还原得2，2′-氨基联苄与1-氯-3-二甲氨基丙烷缩合、成盐制得。

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