CAS号：50-49-7
|
英文名称：IMIPRAMINE
分子式
C19H24N2
分子量
280
EINECS号
200-042-1
MDL
MFCD00242921
Smiles
InChIKey
米帕明化学百科
基本信息
| 中文名称 | 米帕明 |
| 英文名称 | IMIPRAMINE |
| CAS号 | 50-49-7 |
| 分子式 | C19H24N2 |
| 分子量 | 280.41 |
| EINECS号 | 200-042-1 |
物化性质
| 熔点 | 174°C |
| 沸点 | bp0.1 160° |
| 密度 | 0.9935 (rough estimate) |
| 折射率 | 1.5640 (estimate) |
| 形态 | 液体 |
| 酸度系数(pKa) | pKa 9.66(H2O,t = 25,I=0.025) (Uncertain) |
| 颜色 | 无色至浅黄 |
| 水溶解性 | 18.23mg/L(24 ºC) |
| Concentration | 1 mCi/ml |
| Solvent | Ethanol under nitrogen |
| Specific Activity | 60-90 Ci/mmol |
安全信息
| 毒害物质数据 | 50-49-7(Hazardous Substances Data) |
| 毒性 | A tertiary amine tricyclic antidepressant that is thoughtto exert its therapeutic effect by inhibiting the reuptake of serotoninand norepinephrine centrally. A major metabolite is N-desmethylimipramine(desipramine), also used as an antidepressantdrug. Desipramine differs from imipramine in being a betterblocker of norepinephrine, rather than serotonin, uptake. Sideeffects, including sedation and drowsiness, dry mouth, urinaryretention, constipation, and orthostatic hypotension, are probablydue to the anticholinergic, anti-α-adrenergic, and antihistaminergicreceptor-blocking properties. Imipramine should not be usedin conjunction with a monoamine oxidase inhibitor or othertreatment that increases catecholamine concentrations (e.g.,drugs containing sympathomimetic amines). Imipramine shouldbe avoided in patients with cardiovascular disease or seizure disorder,or in those who may abuse alcohol, as imipramine lowersseizure threshold, can produce cardiovascular toxicity and maypotentiate the effects of alcohol. Imipramine intoxication caninclude CNS abnormalities (e.g., drowsiness, stupor, coma, andextrapyramidal symptoms), cardiac arrhythmia, and respiratorydepression. Children appear to be particularly vulnerable to thecardiotoxic and seizure-inducing effects of high doses of imipramine.The oral LD50 in female rats is 305 mg/kg. |
生产及用途
生产方法
由邻硝基甲苯经缩合、还原得2，2′-氨基联苄与1-氯-3-二甲氨基丙烷缩合、成盐制得。
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