| 中文名称 | 依布硒 |
| 英文名称 | Ebselen |
| CAS号 | 60940-34-3 |
| 分子式 | C13H9NOSe |
| 分子量 | 274.18 |
| EINECS号 | 612-054-8 |
| 熔点 | 176-182 °C |
| 沸点 | 402.8±28.0 °C(Predicted) |
| 溶解度 | 易溶于乙醇、甲醇、丙酮、乙腈。 |
| 形态 | 结晶粉末 |
| 酸度系数(pKa) | -0.40±0.20(Predicted) |
| 颜色 | 黄色到米色 |
| 默克索引编号 | 14,3486 |
| 稳定性 | 从购买之日起 2 年内保持稳定。 DMSO 或乙醇溶液可在 -20℃ 下保存长达 3 个月。 |
| 危险品标志 | T,N,Xi |
| 危险类别码 | 23/25-33-50/53-36/37/38 |
| 安全说明 | 20/21-28-45-60-61-28A-36/37-26 |
| 危险品运输编号 | UN 3283 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS号 | DE4140750 |
| 海关编码 | 29310099 |
| 危险等级 | 6.1 |
| 包装类别 | III |
| Target | Value |
|
HIV-1
(Cell-free assay) | 46.1 nM |
Ebselen (SPI-1005; 0.4-100 μM; 20-24 hours) shows strong antiviral effects at a concentration of 10 μM treatment in COVID-19 virus infected Vero cells. Ebsele covalently binds to C145 of the catalytic dyad in COVID-19 virus Mpro.
Ebselen inhibits early viral postentry events of the HIV-1 life cycle by impairing the incoming capsid uncoating process.
Ebselen permeates the blood-brain barrier and inhibits endogenous inositol monophosphatase in mouse brain. Ebselen inhibits inositol monophosphatase (IMPase).
Ebselen inhibits QSOX1 enzymatic activity and suppresses invasion of pancreatic, renal cancer cell lines.
RT-PCR
| Cell Line: | COVID-19 virus infected Vero cells |
| Concentration: | 0.4, 1.2, 3.7, 11.1, 33.3, 100 μM |
| Incubation Time: | 20-24 hours |
| Result: | Showed strong antiviral effects at a concentration of 10 μM treatment. |
Ebselen (5, 10 mg/kg; IP) decreases 5-HT 2 agonist-induced head twitches in a dose-dependent manner.
| Animal Model: | 20-25 g 10-12 week old male C57Bl6 mice |
| Dosage: | 5, 10 mg/kg |
| Administration: | IP |
| Result: | Decreased 5-HT 2 agonist-induced head twitches in a dose-dependent manner. |
