CAS号：78824-30-3
|
英文名称：garcinol
分子式
C38H50O6
分子量
603
EINECS号
200-258-5
MDL
MFCD03700761
Smiles
InChIKey
山竹子素化学百科
基本信息
| 中文名称 | 山竹子素 |
| 英文名称 | garcinol |
| CAS号 | 78824-30-3 |
| 分子式 | C38H50O6 |
| 分子量 | 602.8 |
| EINECS号 | 200-258-5 |
物化性质
| 熔点 | 132 °C |
| 沸点 | 710.8±60.0 °C(Predicted) |
| 密度 | 1.114±0.06 g/cm3(Predicted) |
| LogP | 11.546 (est) |
| 溶解度 | 可溶于DMSO（高达25mg/ml）或乙醇（高达25mg/ml）。 |
| 形态 | 黄色固体 |
| 酸度系数(pKa) | 4.50±1.00(Predicted) |
| 颜色 | 粘黄色 |
| 稳定性 | DMSO中的溶液可在-20°下稳定储存1个月。Garcinol容易氧化。防止暴露在空气中。 |
安全信息
生产及用途
Garcinol 是一种从印度藤黄提取的聚异戊二烯基二苯甲酮，对乙酰胆碱酯酶 (AChE) 和丁酰胆碱酯酶 (BChE) 具有抗胆碱酯酶的特性，IC50 分别为 0.66 µM 和 7.39 µM。Garcinol 还抑制组蛋白乙酰转移酶 (HATs, IC50=7 μM) 和 p300/CPB 相关因子 (PCAF, IC50=5 μM)。Garcinol 具有抗炎和抗癌活性。
|
Human Endogenous Metabolite
|
Garcinol (10-50 µM; 24-72 hours) can inhibit the proliferation of two HNSCC cell lines tested (CAL27 and UMSCC1) in a time- and dose-dependent manner.
Garcinol (10-50 µM; 24-72 hours) induces apoptosis in HNSCC cells.
Garcinol (50 µM; 1-6 hours) suppresses phosphorylation and degradation of the constitutive IκBα in a time-dependent manner.
Cell Proliferation Assay
| Cell Line: | CAL27 and UMSCC1 cells |
| Concentration: | 10, 25, 50 µM |
| Incubation Time: | 24, 48, and 72 hours |
| Result: | Inhibited the proliferation of two HNSCC cell lines in a time- and dose-dependent manner. |
Apoptosis Analysis
| Cell Line: | CAL27 and UMSCC1 cells |
| Concentration: | 10, 25, 50 µM |
| Incubation Time: | 24, 48, and 72 hours |
| Result: | Induced apoptosis in HNSCC cells. |
Western Blot Analysis
| Cell Line: | CAL27 cells |
| Concentration: | 50 µM |
| Incubation Time: | 1, 2, 4, 6 hours |
| Result: | Suppressed phosphorylation and degradation of the constitutive IκBα in a time-dependent manner. |
Garcinol (i.p.; 1 and 2 mg/kg; five times/week for 4 consecutive weeks) induces significant inhibition of tumor growth.
| Animal Model: | Five-week-old athymic nu/nu male mice bearing subcutaneous CAL27 tumors |
| Dosage: | 1 and 2 mg/kg |
| Administration: | I.p.; five times/week for 4 consecutive weeks |
| Result: | Induced significant inhibition of tumor growth. |
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