熔点	208-211 °C (lit.)
比旋光度	D18 -17.6° (c = 1.99 in ethanol)
沸点	485.2°C (rough estimate)
密度	1.32±0.1 g/cm3 (20 ºC 760 Torr)
折射率	1.5100 (estimate)
形态	固体
酸度系数(pKa)	12.00±0.40(Predicted)
颜色	白色至米白色
默克索引编号	13,8253
(IARC)致癌物分类	3 (Vol. 10, Sup 7) 1987

安全信息

危险品标志	T
危险类别码	25
安全说明	22-36/37/39-45
危险品运输编号	1544
WGK Germany	3
RTECS号	VH7525000
危险等级	6.1(a)
包装类别	II
毒害物质数据	480-54-6(Hazardous Substances Data)

生产及用途

生物活性

Retrorsine 是一种天然存在的有毒吡咯利西啶生物碱。Retrorsine 可以与 DNA 结合，抑制肝细胞的增殖能力。Retrorsine 可用于肝细胞损伤的研究。

体外研究

Retrorsine (60-240 μM; 24 hours) significantly reduces HSEC-CYP3A4 cells viability and GSH levels, and increases formation of pyrrole-protein adducts.

Cell Viability Assay

Cell Line:	HSEC-CYP3A4 cells
Concentration:	60 μM, 120 μM , 240 μM
Incubation Time:	24 hours
Result:	Significantly decreased cell viability.

体内研究

Retrorsine (30 mg/kg; i.p.; twice) impairs liver regeneration in the PBL model not only by an S or G2/M phase block, but also by a block located before the G1/S transition of the cell cycle.

Animal Model:	Male Wistar rats (180±20 g), portal branch ligation (PBL) model
Dosage:	30 mg/kg
Administration:	Intraperitoneal injection, twice, separated by 2-week interval
Result:	Strongly impaired the liver weight gain, protein and DNA synthesis as well as induction of cell cycle related proteins in the regenerating lobes after PBL.

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原料药中间体

OLED材料中间体

单质

氢、氮、氧等工业气体

无机碱

无机酸

氧化物和过氧化物

非金属矿

羰基金属

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