| 中文名称 | α-雌二醇 |
| 英文名称 | Estradiol |
| CAS号 | 57-91-0 |
| 分子式 | C18H24O2 |
| 分子量 | 272.39 |
| EINECS号 | 200-354-8 |
| 熔点 | 176-180 °C(lit.) |
| 比旋光度 | D20 +53 to +56° (c = 0.9 in dioxane) |
| 沸点 | 355.44°C (rough estimate) |
| 密度 | 1.0708 (rough estimate) |
| 折射率 | 1.4800 (estimate) |
| 溶解度 | 乙醇：50 mg/mL，澄清，无色 |
| 形态 | 粉末 |
| 酸度系数(pKa) | 10.27±0.60(Predicted) |
| 颜色 | 白色略带黄色 |
| 水溶解性 | 3.9mg/L(25 ºC) |
| 默克索引编号 | 14,3704 |
| 危险品标志 | T,Xn |
| 危险类别码 | 45-48-40 |
| 安全说明 | 53-45-24/25-22 |
| 危险品运输编号 | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS号 | KG3750000 |
| 海关编码 | 29372390 |
|
Human Endogenous Metabolite
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Alpha-Estradiol (17 alpha-Estradiol) is a 5α-reductase inhibitor, and inhibits testosterone metabolism catalyzed by 5 alpha-reductase. Alpha-Estradiol (17 Alpha-estradiol, 10 μM) attenuates LPS-induced inflammatory markers in both C57BL/6J male and female mouse embryonic fibroblast (MEF) cells, primary pre-adipocytes and differentiated 3T3-L1 adipocytes in an ERα-dependent manner, and such effects are through decreased NFκB-p65 and increased ERα protein expression.
Alpha-Estradiol (17-alpha-estradiol, 0.01, 0.1, 1 μg) significantly reduces the percentage of central avascular/total retina area of the mouse pups. Alpha-Estradiol (1 μg) markedly decreasesmalondialdehyde (MDA) levels on postnatal days (PND) 9, 13, and 17 in retinas of hyperoxia-exposed pups. Alpha-Estradiol (1 μg) also decreases the number of NADPH-oxidase-positive cells, NADPH oxidase concentration and activity in retinas of the pups. In the 1.0-μg Alpha-Estradiol-treated pups, VEGF retinal concentrations are high on PND 9 but lower on PND 14 and 17. The best effect in retinas of 1.0-μg Alpha-Estradiol-treated pups is partly reversed by ICI182780 on PND 14 and 17.
Estradiol (known as α-Estradiol or 17 α-Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture. 17α-stradiol and its selective receptor, ER-X, are not part of a cl assical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain.17-Estradiol may have enormous implications for hormone replac ement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer disease and ischemic stroke.
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CAS号:57-91-0
17α-雌二醇 -
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虎红钠盐 -
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CAS号:313-06-4
环戊丙酸雌二醇 -
CAS号:979-32-8
戊酸雌二醇 -
CAS号:87-89-8
肌醇 -
CAS号:57-63-6
炔雌醇 -
CAS号:4956-37-0
庚酸雌二醇 -
CAS号:50-28-2
β-雌二醇 , 雌激素受体 -
CAS号:7004-98-0
表美雌醇 -
CAS号:152-43-2
炔雌醇环戊醚 -
CAS号:57-91-0
17α-雌二醇 -
CAS号:632-69-9
虎红钠盐 -
CAS号:50-50-0
苯甲酸雌二醇 -
CAS号:313-06-4
环戊丙酸雌二醇
