安全信息

危险品标志	Xi
危险类别码	36/37/38-33
安全说明	26-36/37-24/25-37
WGK Germany	3
RTECS号	US7967250
TSCA	T
海关编码	29333999
危险等级	IRRITANT
毒害物质数据	89-00-9(Hazardous Substances Data)
毒性	Focal injection of quinolinic acidinto specific areas of the brain produces neuronal damagealthough sparing axons of passage. Similarities between thebiochemical and morphological profiles of these lesions andhuman neuropathy seen in neurodegenerative diseases have ledto the proposal that endogenous excitotoxins may play a rolein such neurodegenerative disease states. Quinolinic acid is anintermediate in the kynurenine pathway of tryptophan metabolism and has been detected in the brains of several mammalsincluding man. The neuroexcitatory action is thought to bemediated via interaction with the N-methyl-D-aspartate(NMDA) receptor of the glutamate family. No mechanism forquinolinic acid removal, nor for synaptic inactivation, has beenfound, and consequently accumulation of concentrations capa_x0002_ble of inducing neuronal degeneration and death may occur.

生产及用途

2,3-吡啶二甲酸为无色柱状结晶状，微溶于水，不溶于苯和醚。其可用做医药中间体，农药中间体，有机合成试剂。

用途

吡啶-2，3-二羧酸是除草剂咪唑烟酸的中间体。

用途

抑制葡萄糖的合成

用途

喹啉酸是一种具有吡啶骨架的二羧酸，是合成烟酸、菸酰胺、尼可刹米等的中间体，也是铜离子测定试剂。

生产方法

其制备方法是以丙烯醛与草酰乙酸二乙酯、氯化铵为原料，在乙醇中催化剂存在下，反应加热回流，冷却得吡啶-2，3二羧酸酯再水解得产品。

生产方法

用喹啉以硝酸氧化制得。

上下游产品

上游产品共计:26个

下游产品共计:14个