| 中文名称 | 坎利酮 |
| 英文名称 | Canrenone |
| CAS号 | 976-71-6 |
| 分子式 | C22H28O3 |
| 分子量 | 340.46 |
| EINECS号 | 213-554-5 |
| InChI | InChI=1/C22H28O3/c1-20-9-5-15(23)13-14(20)3-4-16-17(20)6-10-21(2)18(16)7-11-22(21)12-8-19(24)25-22/h3-4,13,16-18H,5-12H2,1-2H3/t16-,17+,18+,20+,21+,22-/s3 |
| SMILES | [C@@]12(CCC(=O)O1)CC[C@@]1([H])[C@]3([H])C=CC4=CC(=O)CC[C@]4(C)[C@@]3([H])CC[C@]21C |&1:0,8,10,20,22,26,r| |
| 熔点 | 158-1600C |
| 比旋光度 | D +24.5° (chloroform) |
| 沸点 | 416.25°C (rough estimate) |
| 密度 | 1.1236 (rough estimate) |
| 折射率 | 1.5000 (estimate) |
| LogP | 2.54 at 25℃ |
| 溶解度 | 在DMSO中的溶解度为20mg/mL，澄清 |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
| 旋光性 (optical activity) | [α]/D +17 to +24°, c = 1 in chloroform-d |
| 水溶解性 | 272.4ug/L(25 ºC) |
| 危险品标志 | Xn,N |
| 危险类别码 | 40-51/53 |
| 安全说明 | 36/37-61 |
| 危险品运输编号 | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| 海关编码 | 29329990 |
|
Human Endogenous Metabolite
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Canrenone inhibits the production of eortieosterone, 18-hydroxydesoxyeortieosterone, 18-hydroxycorticosterone and aldosterone in a dose-dependent manner. Canrenone dose-dependently reduces platelet-derived growth factor–induced cell proliferation and motility. Canrenone inhibits the activity of the Na + /H + exchanger 1 induced by platelet-derived growth factor.
Canrenone is the principal active metabolite of Spironolactone in the rat only for a limited period. During chronic treatment a difference developed between the effect of Spironolactone and Canrenone on the RAAS indicating a decrease in the anti-mineralocorticoid activity of Canrenone and an increase in the efficacy of Spironolactone.
坎雷诺酮(螺内酯EP杂质F)是醛固酮拮抗剂。利尿剂。用于治疗心衰水肿和肝硬变腹水。
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